121 articles - From Friday Feb 16 2024 to Friday Feb 23 2024
Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…
| Aliment Pharmacol Ther |
|---|
UK guideline on the transition and management of childhood liver diseases in adulthood. These are the first nationally developed guidelines on the transition and management of childhood liver diseases in adulthood. They provide a framework upon which to base clinical care, which we envisage will lead to improved outcomes for YA with chronic liver disease. |
| Clin Gastroenterol Hepatol |
AGA Clinical Practice Update on High-Quality Upper Endoscopy: Expert Review. BEST PRACTICE ADVICE 9: Endoscopists should document whether subsequent surveillance endoscopy is indicated and, if so, provide appropriate surveillance intervals. If the determination of surveillance is contingent on histopathology results, then endoscopists should document that surveillance intervals will be suggested after results are available. |
meta-analyses and systematic reviews
| Aliment Pharmacol Ther |
|---|
Meta-analysis: Risk of pancreatic cancer in patients with inflammatory bowel disease. Our results suggest a moderate increase in the risk of pancreatic cancer in patients with IBD, which may be further heightened by genetic predisposition to IBD. The increased risk of pancreatic cancer is probably similar in Crohn's disease and ulcerative colitis. |
| Am J Gastroenterol |
| Clin Gastroenterol Hepatol |
Global Epidemiology of Gallstones in the 21st Century: A Systematic Review and Meta-analysis. Globally, 6% of the population have gallstones, with higher rates in females and in South America. The incidence of gallstones may be rising. Our findings call for prioritizing research on prevention of gallstones. |
| Endoscopy |
Prevalence Of Endoscopy Related Injuries and Its Impact on Clinical Practice: A Systematic Review and Meta-Analysis. Endoscopy related injuries of CTS, DQTS and endoscopy related pain are very common. These injuries can be severe, requiring surgery, and lead to loss of productivity. Most gastroenterologist report an unmet need for training in proper ergonomics of endoscopy. |
| Gastrointest Endosc |
Diagnostic yield of endoscopic and EUS-guided biopsy techniques in subepithelial lesions of the upper gastro-intestinal tract: a systematic review. Based on the available evidence, MIAB and EUS-FNB seem to be most effective in terms of achieving a high diagnostic yield, with similar rates of adverse events. |
RCT, clinical trials, retrospective studies, etc…
| Aliment Pharmacol Ther |
|---|
Drug-induced liver injury from selective androgen receptor modulators, anabolic-androgenic steroids and bodybuilding supplements in Australia. The prognosis of DILI from AAS, SARMs and BBS is good although liver transplantation may rarely be required. A detailed drug history is important in uncovering DILI due to these supplements. |
Upper limit of normal ALT levels in health and metabolic diseases: Pooled analysis of 423,355 individuals with bootstrap modelling. We provide expected ranges of ALT ULN levels for individuals without known liver disease without metabolic diseases and those with or without T2DM and/or are normal weight or overweight/obese. These data may have implications for clinical care and screening. |
| Am J Gastroenterol |
Does surgery prior to pregnancy in women with inflammatory bowel disease increase the risk of adverse maternal and fetal outcomes? A Danish national cohort study. Providers should be aware there is an increased likelihood of C-section and certain perinatal complications in patients with CD or UC surgery prior to pregnancy. |
Role of the intestine and its gut microbiota in metabolic syndrome and obesity. In addition, we have reviewed the existing evidence of the gut microbiome and its association with and impact on metabolic disorders, in an attempt to understand the complex interactions and nature of this association. We also explored potential therapeutic options targeting the gut to modify metabolic disorders and obesity. |
| Clin Gastroenterol Hepatol |
ASSOCIATION BETWEEN CELIAC DISEASE AND IRRITABLE BOWEL SYNDROME: A NATIONWIDE COHORT STUDY. In patients with CD, the risk of IBS is increased long before and after diagnosis. Clinicians should be aware of these long-term associations and their implications on patient management. |
DNA methylation profiling enables accurate classification of non-ductal primary pancreatic neoplasms. Pancreatic neoplasms can be classified with high accuracy based on DNA methylation signatures. Additionally, non-pancreatic neoplasms are identified with near perfect precision. In summary, methylation profiling can serve as a valuable adjunct in the diagnosis of pancreatic neoplasms with minimal risk for misdiagnosis, even in the pre-operative setting. |
Heartburn Relief is the Major Unmet Need for Drug Development in Gastroesophageal Reflux Disease: Threshold Value Analysis. We demonstrate that aiming GERD-related drug development toward heartburn relief appears critical to align cost-effective incentives for industry and insurers with those of patients and gastroenterologists. |
Long-Term Effectiveness and Durability of COVID-19 Vaccination among Patients with Inflammatory Bowel Disease. COVID-19 vaccination generates an effective and durable protective response for the vast majority of adults with IBD, including vulnerable populations such as corticosteroid users and older individuals. Patients with IBD benefit from COVID-19 booster vaccination. |
| Endosc Int Open |
Trends in prevalence of esophageal adenocarcinoma: Findings from a statewide database of over 6 million patients. Therefore, we aimed to assess the time trends in the prevalence and incidence of EAC and some of its risk factors in a large population of patients in Florida and to assess these trends based on age categories. We hypothesized that the prevalence of EAC and BE has increased over time at younger age groups. |
| Endoscopy |
Pan-intestinal capsule endoscopy as first-line procedure in patients with suspected mid or lower gastrointestinal bleeding. While assessing patients with MLGIB, PCE dismisses further invasive procedures in more than half of patients. Moreover, PCE is safe and more effective than colonoscopy in identifying PHL both in the small-bowel and colon. Our results support the potential use of PCE as first-line examination in patients with suspected MLGIB. |
Prevalence and predictive factors of colorectal sessile serrated lesions in younger individuals. SSLs are not uncommon among younger individuals. Moreover, diligent effort and expertise are of paramount importance in SSL detection. Future studies should explore the clinical significance of SSLs in younger age individuals. |
Vertical R1 margins are not always associated with residual neoplasia after endoscopic resection of Barrett's neoplasia: a nationwide cohort with dedicated pathology reassessment. Histological evaluation of ER margins appears challenging as 75% of documented R1v cases were confirmed during reassessment. After ER with R1v, 50% of the patients had no residual neoplasia. Endoscopic reassessment 8-12 weeks after ER seems accurately able to detect residual neoplasia and help to determine the most appropriate strategy for patients with R1v. |
| Gastroenterology |
Endoscopic gallbladder stenting to prevent recurrent cholecystitis in deferred cholecystectomy: a randomized trial. ETGS could prevent recurrent cholecystitis in acute cholecystitis patients with CBD stone whose cholecystectomy was deferred for 3 months. In those who did not receive ETGS, the majority of recurrences occurred within 3 months. (Thaiclinicaltrials.org, number TCTR20200913001). |
Thalidomide for Recurrent Small Intestinal Gastrointestinal Bleeding. endoscopic ablation, angiographic embolization, or surgical resection). Thalidomide is an immunomodulatory drug that down-regulates vascular endothelial growth factor and has been used to treat SIA, although its evidence in this setting is limited to observational and open-label trials. |
| Gastrointest Endosc |
Endoscopic ultrasound-guided hepaticogastrostomy versus hepaticogastrostomy with antegrade stenting in patients with unresectable malignant distal biliary obstruction: a propensity score-matched case-control study. EUS-HGAS extended TRBO compared with EUS-HGS, while AEs, except for RBO and OS, did not differ. The longer TRBO of EUS-HGAS could benefit patients with longer life expectancy. |
Fixation of Proximal flange of Lumen Apposing Metal Stent using Through-the-Scope Endoscopic Suturing System to Prevent Stent Migration in Single-Session EUS-directed Transgastric ERCP: A Pilot Study. Use of through-the-scope endoscopic suturing can be a safe, reliable, and potentially cost-effective novel technique for LAMS fixation to successfully perform SS-EDGE in RYGB patients. |
| Gut |
Association of healthy lifestyle behaviours with incident irritable bowel syndrome: a large population-based prospective cohort study. Adhering to a higher number of healthy lifestyle behaviours is significantly associated with a lower incidence of IBS in the general population. Our findings suggest the potential of lifestyle modifications as a primary prevention strategy for IBS. |
Serum biomarker signature is predictive of the risk of hepatocellular cancer in patients with cirrhosis. We identified a panel of nine serum biomarkers that is independently associated with developing HCC in cirrhosis and that improved the predictive ability of risk stratification models containing clinical factors. |
| Hepatology |
A modified hospital frailty risk score for patients with cirrhosis undergoing abdominal operations. While the 109-component HFRS was associated with adverse surgical outcomes, 12 components accounted for much of the association between the HFRS and mortality. We developed the cirrhosis-HFRS, a tool that demonstrates superior predictive accuracy for in-hospital mortality and more precisely reflects the specific comorbidity pattern of hospitalized patients with cirrhosis undergoing general surgery procedures. |
ASK1/p38 axis inhibition blocks the release of mitochondrial "danger signals" from hepatocytes and suppresses progression to cirrhosis and liver cancer. ASK1 inhibition suppresses profibrogenic release of mtDNA from dying hepatocytes in p38-dependent manner and protects from liver fibrosis. Long-term ASK1 targeting resulted in diminished net antifibrotic effect, but the progression to liver cirrhosis and cancer in BALBc/Mdr2-/- mice was effectively inhibited. These data support the clinical evaluation of ASK1 inhibitors in fibrotic liver diseases. |
Enhanced SLC35B2/SAV1 sulfation axis promotes tumor growth through inhibiting Hippo signaling in hepatocellular carcinoma. Our findings reveal a regulatory mechanism of SLC35B2/SAV1 sulfation axis in response to oxidative stress, highlighting its potential as a promising therapeutic target for HCC. |
Extensive splanchnic vein thrombosis after SARS-CoV-2 vaccination a Vascular Liver Disease Group (VALDIG) initiative. Although definite VITT was rare, in 72% no other cause for SVT could be identified following SARS-CoV-2 vaccination. These cases were different from patients with non-vaccine related SVT, with lower incidence of prothrombotic conditions, higher rates of bowel ischemia and poorer outcome. Although SVT after SARS-CoV-2 vaccination is rare in absolute terms, these data remain relevant considering ongoing re-vaccination programs. |
Genome-wide association study identifies high-impact susceptibility loci for hepatocellular carcinoma in North America. Our GWAS highlights novel genetic susceptibility of non-viral HCC among EDP from North America with substantial heritability. Selected genetic influences were observed for HCV-positive HCC. Our findings indicate the importance of genetic susceptibility to HCC development. |
Genomics of human NAFLD: Lack of data reproducibility and high interpatient variability in drug target expression as major causes of drug failures. Lack of data reproducibility, high interpatient variability and absence of disease dependent drug target regulations are likely causes of NASH drug failures in clinical trials. |
Impending hepatocellular carcinoma diagnosis in cirrhotic patients after HCV cure features a natural killer cell signature. We show that HCV-related HCC development has profound effects on the imprint of NK cells. Persistent co-expression of TIM-3hi and CD38+ on NK cells is an early indicator for HCV-related HCC development. We propose profiling of NK cells may be a rapid and valuable tool to assess the risk of HCC development in a timely manner in cirrhotic patients after HCV cure. |
Integrative transcriptomic and genomic analyses unveil the IFI16 variants and expression as a MASLD progression markers. This study unveils a comprehensive understanding of MASLD progression through transcriptomic classification, highlighting the crucial roles of IFI16 variants. Targeting the IFI16-PYCARD-CASP1 pathway may pave the way for the development of novel diagnostics and therapeutics for MASLD. |
Oleic acid-PPARγ-FABP4 loop fuels cholangiocarcinoma colonization in lymph node metastases microenvironment. Our results reveal the role of the oleic acid-PPARγ-FABP4 loop in fueling cholangiocarcinoma colonization in lymph nodes, and demonstrate that PPARγ-regulated lipid metabolic reprogramming is a promising therapeutic target for relieving cholangiocarcinoma lymph node metastasis burden and reducing further progression. |
Recent outcomes of liver transplantation for Budd Chiari Syndrome - a study of the European Liver Transplant Registry (ELTR) and affiliated centers. LT for BCS results in excellent patient- and graft survival. Older recipient or donor age, and higher MELD are associated with poorer outcomes, while long-term anticoagulation improves both patient and graft outcomes. |
Serum aryl hydrocarbon receptor activity is associated with survival in patients with alcohol-associated hepatitis. Serum AhR activity was significantly higher in patients with AH compared with controls and individuals with AUD, and this increased activity was associated with higher mortality. Consequently, serum AhR activity holds potential as a prognostic marker. |
Sintilimab plus bevacizumab combined with radiotherapy as first-line treatment for hepatocellular carcinoma with portal vein tumor thrombus: A multicenter, single-arm, phase 2 study. Sintilimab plus bevacizumab combined with radiotherapy provides favorable treatment response and survival outcomes along with an acceptable safety profile in the first-line setting for HCC patients with PVTT. (ClinicalTrials.gov Identifier NCT05010434). |
| J Hepatol |
Exploring the impact of the PNPLA3 I148M variant on primary human hepatic stellate cells using 3D extracellular matrix models. HSCs carrying the PNPLA3 I148M variant have impaired mitochondrial function, antioxidant response, and increased TGFB1 signalling dampening the antifibrotic NR4A1 activity. These features are exacerbated by cirrhotic ECM, highlighting the dual impact of the PNPLA3 I148M variant and the fibrotic microenvironment in progressive chronic liver diseases. Impact and implications Hepatic stellate cells (HSCs) play a key role in the fibrogenic process associated with chronic liver disease. The PNPLA3 genetic mutation has been linked with increased risk of fibrogenesis, but its role in HSCs needs further investigation. Here, by using comparative transcriptomic and a novel 3D in vitro model, we demonstrate the impact of the PNPLA3 genetic mutation on primary human HSCs cell behaviour, and we show that it affects the cell's mitochondrial function and antioxidant response, as well as the antifibrotic gene NR4A1. Our publicly available transcriptomic data, 3D platform and our findings on NR4A1 could facilitate the discovery of targets to develop more effective treatments for chronic liver diseases. |
Plenty of the editorials are available as full text through the publisher website using the provided link
| Clin Gastroenterol Hepatol |
|---|
The Emerging Role of Glucagon-Like Peptide-1 Receptor Agonists for the Treatment of Metabolic- Dysfunction Associated Steatohepatitis. This review summarizes the role of glucagon-like peptide (GLP) -1 receptor agonists in treating MASLD/MASH. Although not approved by the Food and Drug Administration for the treatment of MASLD, this class of medication is available to treat obesity and type 2 diabetes and has been shown to reverse steatohepatitis, reduce cardiovascular risk, and is safe to use across the spectrum of MASLD with or without fibrosis. |
| Gastrointest Endosc |
| Gut |
Coeliac disease: the paradox of diagnosing a food hypersensitivity disorder with autoantibodies. The immunological mechanisms underlying the formation of autoantibodies in response to gluten exposure have been dissected. This review presents the current insights demonstrating that the autoantibodies in coeliac disease are intimately integrated in the maladapted immune response to gluten. |
| J Hepatol |
misc publications eg case reports, tools of the trade, images of the month, etc…
| Am J Gastroenterol |
|---|
| Clin Gastroenterol Hepatol |
| Endoscopy |
| Gastroenterology |
| Gastrointest Endosc |
| Gut |
| Hepatology |
| J Hepatol |
Letters to the editors and authors’ replies
| Clin Gastroenterol Hepatol |
|---|
| Gastroenterology |
| Gastrointest Endosc |
| Gut |
| J Hepatol |